Download AKTU B-Pharm 5th Sem Syllabus PDF

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BP501T. MEDICINAL CHEMISTRY – II (Theory)

Unit-I

Antihistaminic agents: Histamine, receptors and their distribution in the human
body.
H1–antagonist: Diphenhydramine hydrochloride*, Dimenhydrinate, Doxylamine
succinate, Clemastine fumarate, Diphenylpyraline hydrochloride, Triphelenamine
hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine
hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride*, Phenidamine
tartrate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine
hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrizine
Cromolyn sodium.
H2-antagonists: Cimetidine*, Famotidine, Ranitidine.
Gastric proton-pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole.
Anti-neoplastic agents:
Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan,
Chlorambucil, Busulfan, Thiotepa.
Antimetabolites: Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine,
Methotrexate*, Azathioprine.
Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin.
Plant products: Etoposide, Vinblastine sulphate, Vincristine sulphate.
Miscellaneous: Cisplatin, Mitotane.

Unit-II

Anti-anginal: Vasodilators: Amyl Nitrite, Nitroglycerin*, Pentaerythritol tetranitrate,
Isosorbide dinitrite*, Dipyridamole.
Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem
hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
Diuretics: Carbonic Anhydrase Inhibitors: Acetazolamide*, Methazolamide,
Dichlorphenamide.
Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide,
Loop Diuretics: Furosemide*, Bumetanide, Ethacrynic acid.
Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride. Osmotic Diuretics:
Mannitol.
Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril, Benazepril
hydrochloride, Quinapril Hydrochloride, Methyldopate Hydrochloride* Clonidine
hydrochloride, Guanethidine Monosulphate, Guanabenz Acetate, Sodium Nitroprusside,
Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.

Unit-III

Anti-arrhythmic Drugs: Quinidine Sulphate, Procainamide Hydrochloride, Disopyramide
Phosphate*, Phenytoin Sodium, Lidocaine Hydrochloride, Tocainide Hydrochloride,
Mexiletine Hydrochloride, Lorcainide Hydrochloride, Amiodarone, Sotalol.
Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholestyramine and Colestipol.
Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin*, Anisindione,
Clopidogrel.
Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide, Bosentan,
Tezosentan.

Unit-IV

Drugs acting on Endocrine system: Nomenclature, Stereochemistry and metabolism of
steroids.
Sex hormones: Testosterone, Andralone, Progestrones, Oestriol, Oestradiol, Oestrione,
Diethyl Stilbestrol.
Drugs for erectile dysfunction: Sildenafil, Tadalafil.
Oral contraceptives: Mifepristone, Norgestrel, Levonorgestrel
Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone,
Dexamethasone.
Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil,
Methimazole.

Unit-V

Antidiabetic agents: Insulin and its preparations.
Sulfonylureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride.
Biguanides: Metformin.
Thiazolidinediones: Pioglitazone, Rosiglitazone, Meglitinides, Repaglinide, Nateglinide.
Glucosidase inhibitors: Acarbose, Voglibose.
Local Anesthetics: SAR of Local anesthetics.
Benzoic acid derivatives; Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine,
Piperocaine.
Amino Benzoic acid derivatives: Benzocaine*, Butamben, Procaine*, Butacaine,
Propoxycaine, Tetracaine, Benoxinate.
Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine.
Miscellaneous: Phenacaine, Diperodon, Dibucaine.

BP502T. INDUSTRIAL PHARMACY I (Theory)

Unit-I

Pre-formulation Studies: Introduction to pre-formulation, goals and objectives, study of
physicochemical characteristics of drug substances.
Physical properties: Physical form (crystal & amorphous), particle size, shape, flow
properties, solubility profile (pKa, pH, partition coefficient), polymorphism.
Chemical Properties: Hydrolysis, oxidation, reduction, racemization, polymerization.
BCS classification of drugs & its significance.
Application of pre-formulation considerations in the development of solid, liquid oral and
parenteral dosage forms and its impact on stability of dosage forms.

Unit-II

Tablets:
Introduction, ideal characteristics of tablets, classification of tablets. Excipients,
Formulation of tablets, granulation methods, compression and processing problems.
Equipment’s and tablet tooling.
Tablet coating: Types of coating, coating materials, formulation of coating composition,
methods of coating, equipment employed and defects in coating. Quality control tests: In
process and finished product tests.
Liquid orals:
Formulation and manufacturing consideration of syrups and elixirs suspensions and
emulsions; Filling and packaging; evaluation of liquid orals official in Pharmacopoeia.

Unit-III

Capsules:
Hard gelatin capsules: Introduction, Production of hard gelatin capsule shells. Size of
capsules, Filling, finishing and special techniques of formulation of hard gelatin capsules,
manufacturing defects. In process and final product quality control tests for capsules.
Soft gelatin capsules: Nature of shell and capsule content, size of
capsules, importance of base adsorption and minim/gram factors, production, in process
and final product quality control tests. Packing, storage and stability testing of soft
gelatin capsules and their applications.
Pellets: Introduction, formulation requirements, palletization process, and equipment for
manufacture of pellets.

Unit-IV

Parenteral Products:
Definition, types, advantages and limitations. Preformulation factors and essential
requirements, vehicles, additives, importance of isotonicity.
Production procedure, production facilities and controls, aseptic processing.
Formulation of injections, sterile powders, large volume parenteral and lyophilized
products.
Containers and closures selection, filling and sealing of ampoules, vials and infusion
fluids. Quality control tests of parenteral products.
Ophthalmic Preparations: Introduction, formulation considerations; formulation of eye
drops, eye ointments and eye lotions, methods of preparation, labeling, containers,
evaluation of ophthalmic preparations.

Unit-V

Cosmetics: Formulation and preparation of the following cosmetic preparations: lipsticks,
shampoos, cold cream and vanishing cream, tooth pastes, hair dyes and sunscreens.
Pharmaceutical Aerosols: Definition, propellants, containers, valves, types of aerosol
systems, formulation and manufacture of aerosols, Evaluation of aerosols, Quality control
and stability studies.
Packaging Materials Science: Materials used for packaging of pharmaceutical products,
factors influencing choice of containers, legal and official requirements for containers,
stability aspects of packaging materials, quality control tests.

BP503T. PHARMACOLOGY-II (Theory)

Unit-I

Pharmacology of drugs acting on cardio-vascular system
Introduction to hemodynamic and electrophysiology of heart Drugs used in congestive heart failure.
Anti-hypertensive drugs.
Anti-anginal drugs.
Anti-arrhythmic drugs.
Anti-hyperlipidemic drugs.

Unit-II

Pharmacology of drugs acting on cardio vascular system
Drug used in the therapy of shock.
Hematinics, coagulants and anticoagulants.
Fibrinolytics and anti-platelet drugs.
Plasma volume expanders.
Pharmacology of drugs acting on urinary system
Diuretics.
Anti-diuretics.

Unit-III

Autacoids and related drugs
Introduction to autacoids and classification of Histamine, 5-HT and their antagonists.
Prostaglandins, Thromboxanes and Leukotrienes.
Angiotensin, Bradykinin and Substance P.
Non-steroidal anti-inflammatory agents.
Antigout drugs, Anti rheumatic drugs.

Unit-IV

Pharmacology of drugs acting on endocrine system
Basic concepts in endocrine pharmacology.
Anterior Pituitary hormones- analogues and their inhibitors.
Thyroid hormones- analogues and their inhibitors.
Hormones regulating plasma calcium level- Parathormone, Calcitonin and Vitamin D.
Insulin, Oral Hypogl ycemic agents and glucagon. ACTH and corticosteroids.

Unit-V

Pharmacology of drugs acting on endocrine system
Androgens and Anabolic steroids. Estrogens, progesterone and oral contraceptives. Drugs acting on the
uterus.
Bioassay
Principles and applications of bioassay. Types of bioassay.
Bioassay of insulin, oxytocin, vasopressin, ACTH, d-tubocurarine, digitalis, histamine and 5-HT.

BP504T. PHARMACOGNOSY AND PHYTOCHEMISTRY II (Theory)

Unit-I

Metabolic pathways in higher plants and their determination
Brief study of basic metabolic pathways and formation of different secondary metabolites
through these pathways- Shikimic acid pathway, Acetate pathways and Amino acid
pathway. Study of utilization of radioactive isotopes in the investigation of Biogenetic
studies.

Unit-II

General introduction, composition, chemistry & chemical classes, bio -sources, therapeutic
uses and commercial applications of following secondary metabolites:
Alkaloids: Vinca, Rauwolfia, Belladonna, Opium.
Phenylpropanoids and Flavonoids: Lignans, Tea, Ruta.
Steroids, Cardiac Glycosides & Triterpenoids: Liquorice, Dioscorea, Digitalis.
Volatile oils: Mentha, Clove, Cinnamon, Fennel, Coriander.
Tannins: Catechu, Pterocarpus.
Resins: Benzoin, Guggul, Ginger, Asafoetida, Myrrh, Colophony.
Glycosides: Senna, Aloes, Bitter Almond.
Iridoids, Other terpenoids & Naphthaquinones: Gentian, Artemisia, Taxus, carotenoids.

Unit-III

Isolation, Identification and Analysis of Phytoconstituents.
Terpenoids: Menthol, Citral, Artemisin.
Glycosides: Glycyrhetinic acid & Rutin.
Alkaloids: Atropine, Quinine, Reserpine, Caffeine
Resins: Podophyllotoxin, Curcumin.

Unit-IV

Industrial production, estimation and utilization of the following phytoconstituents:
Forskolin, Sennoside, Artemisinin, Diosgenin, Digoxin, Atropine, Podophyllotoxin,
Caffeine, Taxol, Vincristine and Vinblastine.

Unit-V

Basics of Phytochemistry
Modern methods of extraction, application of latest techniques like Spectroscopy,
Chromatography and electrophoresis in the isolation, purification and identification of
crude drugs

BP505T. PHARMACEUTICAL JURISPRUDENCE (Theory)

Unit-I

Drugs and Cosmetics Act, 1940 and its rules 1945:
Objectives, Definitions, Legal definitions of schedules to the Act and Rules.
Import of drugs – Classes of drugs and cosmetics prohibited from import, Import under
license or permit. Offences and penalties.
Manufacture of drugs – Prohibition of manufacture and sale of certain drugs,
Conditions for grant of license and conditions of license for manufacture of drugs,
Manufacture of drugs for test, examination and analysis, manufacture of new drug, loan
license and repacking license.

Unit-II

Drugs and Cosmetics Act, 1940 and its rules 1945
Detailed study of Schedule G, H, M, N, P, T, U, V, X, Y, Part XII B, Sch F & DMR (OA)
Sale of Drugs – Wholesale, Retail sale and restricted license. Offences and penalties.
Labeling & Packing of drugs- General labeling requirements and specimen labels for
drugs and cosmetics, List of permitted colors. Offences and penalties.
Administration of the Act and Rules– Drugs Technical Advisory Board, Central drugs
Laboratory, Drugs Consultative Committee, Government drug analysts, licensing
authorities, controlling authorities, Drugs Inspectors.

Unit-III

Pharmacy Act-1948: Objectives, Definitions, Pharmacy Council of India; its constitution
and functions, Education Regulations, State and Joint state pharmacy councils;
constitution and functions, Registration of Pharmacists, Offences and Penalties.
Medicinal and Toilet Preparation Act-1955: Objectives, Definitions, Licensing,
Manufacture In bond and Outside bond, Export of alcoholic preparations,
Manufacture of Ayurvedic, Homeopathic, Patent & Proprietary Preparations.
Offences and Penalties.
Narcotic Drugs and Psychotropic substances Act-1985 and Rules: Objectives,
Definitions, Authorities and Officers, Constitution and Functions of narcotic &
Psychotropic Consultative Committee, National Fund for Controlling the Drug Abuse,
Prohibition, Control and Regulation, opium poppy cultivation and production of poppy
straw, manufacture, sale and export of opium, Offences and Penalties.

Unit-IV

Study of Salient Features of Drugs and Magic Remedies Act and its
rules: Objectives, Definitions, Prohibition of certain advertisements, Classes of Exempted
advertisements, Offences and Penalties.
Prevention of Cruelty to animals Act-1960: Objectives, Definitions, Institutional
Animal Ethics Committee, CPCSE guidelines for Breeding and Stocking of Animals,
Performance of Experiments, Transfer and acquisition of animals for experiment, Records,
Power to suspend or revoke registration, Offences and Penalties.
National Pharmaceutical Pricing Authority: Drugs Price Control Order (DPCO)-
2013. Objectives, Definitions, Sale prices of bulk drugs, Retail price of formulations,
Retail price and ceiling price of scheduled formulations, National List of Essential
Medicines (NLEM).

Unit-V

Pharmaceutical Legislations – A brief review, Introduction, Study of drugs enquiry
committee, Health survey and development committee, Hathi committee and Mudaliar
committee.
Code of Pharmaceutical ethics – Definition, Pharmacist in relation to his job, trade,
medical profession and his profession, Pharmacist’s oath.

 

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